Kroon Radiology, Leiden University Medical Center, Leiden, The Netherlands van Noort-Suijdendorp Orthopedic Surgery, IJsselland Hospital, Cappelle aan den IJssel, The Netherlands H. O Orthopedic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands A. Bramer Orthopedic Surgery, Academic Medical Center, Amsterdam, The Netherlands ¨ ner F. Patients present with lower back pain, frequently radiating to the legs, and sometimes with bladder, rectal or sexual dysfunction. The sacrum is the most affected bone of the axial skeleton, accounting for 2–8 % of all GCT. Keywords Giant cell tumor of bone Sacral giant cell tumor Sacrum Curettage Local adjuvant Introduction Giant cell tumor of bone (GCT) is a benign, locally aggressive primary bone tumor, mostly affecting metaepiphyseal regions of long bones. Complications were common and impaired function. Conclusion Recurrence rate for sacral GCT was highest after isolated curettage, indicating that (local) adjuvant treatment is desired to obtain immediate local control. MSTS was superior in patients without complications (27 vs. van Royen Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands Schreuder Orthopedic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands B.
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Results Recurrence rate was 14/26 after median 13 (3–139) months and was highest after isolated curettage (4/ 5). Statistics were performed with Kaplan– Meier, Cox regression, log rank and Mann–Whitney U. Functional outcome was assessed using Musculoskeletal Tumor Society (MSTS) score.
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All patients underwent intralesional excision, 21 with local adjuvants, 5 radiotherapy, 3 IFN-a, 1 bisphosphonates. Methods We retrospectively studied all 26 patients treated for sacral GCT in the Netherlands (from 1990 to 2010). Received: 10 October 2013 / Revised: 20 February 2014 / Accepted: 20 February 2014 Ó Springer-Verlag Berlin Heidelberg 2014Ībstract Purpose Evaluation of recurrences, complications and function at mid-term follow-up after curettage for sacral giant cell tumor (GCT). doi: 10.1302/ cell tumors of the sacrum-a nationwide study on midterm results in 26 patients after intralesional excision L. Limb-sparing surgery preserves more function than amputation: a Scandinavian sarcoma group study of 118 patients. doi: 10.1007/s1043-3.Īksnes LH, Bauer HC, Jebsen NL, Folleras G, Allert C, Haugen GS, Hall KS. Amputation for recurrent soft tissue sarcoma of the extremity: indications and outcome. Stojadinovic A, Jaques DP, Leung DH, Healey JH, Brennan MF. Less is (usually) more: when is amputation appropriate for treatment of extremity soft tissue sarcoma? Ann Surg Oncol. Early results of lower limb surgery for osteogenic sarcoma of bone. Surgical options and outcomes in bone sarcoma. Through application of the Chinese MSTS, we demonstrated that patients receiving limb-salvage surgeries may have better functional outcome and QoL than those undergoing amputation surgeries.Įxtremity sarcoma MSTS Outcome Reliability Validity. The Chinese MSTS scoring system is a reliable and valid instrument with well-accepted psychometric properties. The factor analysis indicated a 1-factor model with acceptable goodness of fit. 23.5 ± 6.3, p = 0.005), which indicated a good discrinimant validity of the Chinese MSTS. Patients undergoing amputation surgery had remarkably lower MSTS score than patients undergoing limb-salvage surgeries (18.8 ± 5.4 vs. The test for internal consistency showed a Cronbach's α of 0.86 for the MSTS.
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The ICC was 0.91 (95% confidence interval (CI) = 0.85-0.96) for the test-retest reliability and 0.90 (95% CI = 0.86-0.93) for the inter-observer analysis. The construct validity was evaluated with the factor analysis. The discriminant validity was evaluated through comparison of the MSTS score between patients undergoing amputation surgeries and those undergoing limb-salvage surgeries. The internal consistency was evaluated by Cronbach's α, with a value >0.70 considered acceptable. The inter-observer and test-retest reliability was analyzed with intra-class correlation coefficient (ICC). The reliability of Chinese MSTS was evaluated through test-retest analysis, inter-observer analysis and internal consistency. Assessment of psychometric properties was carried out through reliability and validity test. All the patients completed the clinical assessment with the Chinese MSTS and the Chinese Toronto Extremity Salvage Score (TESS). This study aims to investigate the reliability and validity of the Chinese version of the MSTS, and to evaluate functional outcomes of the surgical treatment of lower extremity sarcoma using the Chinese MSTS.Ī cohort of 98 patients who had undergone surgery for lower extremity sarcoma were included. The Musculoskeletal Tumor Society (MSTS) scoring system is a disease-specific instrument to determine the physical and mental health for patients with extremity sarcoma.